---

Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance introduces the basic concepts and advanced understanding of cancer stem cells, covering general overviews, organ-specific identifications, and their characteristic mechanisms. The book also explores innovative therapeutic strategies in preclinical and clinical trials to target cancer stem cells, remove the roots of cancer, eliminate the seeds of metastasis, overcome the resistance of therapies, and contribute to the eradication of cancer.

The book includes contributions from leading, worldwide experts in the field, helping readers embrace new hope in their quest to eradicate cancer with emerging clinical trials on treating cancer stem cells in combination with other therapies.

Provides an authoritative and complete overview of cancer stem cells
Includes comprehensive coverage of current therapeutic strategies targeting cancer stem cells
Deepens a reader´s technical expertise in cancer stem cell biology

---

Foreword by Jane Visvader and Stanton Gerson Section I. CSC Overview and Methodology

1. Introduction: Cancer Stem Cells Siddhartha S. Mitra, Joy He, Rogelio Esparza, Gregor Hutter, Samuel H. Cheshier and Irving Weissman

2. Overview: Cancer Stem Cell Self-Renewal Maider Zabala, Neethan A. Lobo, Dalong Qian, Linda J. van Weele, Diane Heiser and Michael F. Clarke

3. Enrichment and Interrogation of Cancer Stem Cells Awad Jarrar, Anastasia Chumakova, Masahiro Hitomi, Justin Lathia

Section II. CSCs in Representative Organ systems

4. Critical Updates to the Leukemia Stem Cell Model Yogen Saunthararajah

5. Breast cancer stem cells and the move toward high resolution stem cell systems Benjamin T. Spike

6. Lung Cancer Stem Cells: Drivers of Genetically and Histologically Complex Disease Christine M. Fillmore and Carla F. Kim

7. Colorectal cancer stem cells Sumaiyah Rehman, Jennifer Haynes, Evelyne Lima-Fernandes, Akshita Puri, Andrew Haller, Cherry Leung, Lauren Agro, Yadong Wang, and Catherine A. O´Brien

8. Targeting Bladder Cancer Stem Cells: One-Step Closer To The Clinic? Antonina Kurtova and Keith Syson Chan

9. Cancer Stem Cells as New therapeutic Targets for Ovarian Cancer Yinu Wang, Fang Fang, Salvatore Condello, Daniela Matei and Kenneth P. Nephew

Section III. CSC Features and Mechanisms

10. Understanding Cancer Cells of Origin in Cutaneous Tumors Hyeongsun Moon, Leanne R. Donahue, Andrew C. White

11. Asymmetric Division of Cancer Stem Cells Claudia Petritsch and Xiling Shen

12. Metastasis and Metastatic Cells: A Historical Perspective and Current Analysis Kiera Rycaj and Dean G. Tang

13. Metastasis and Evasion from the Host Immune Responses Avijeet Chopra, Xia Liu, Huiping Liu

14. Cancer Stem Cells and Tumor Associated Macrophages Wenchao Zhou and Shideng Bao

15. The Mechanisms of Therapy Resistance in Cancer Stem Cells Chi-Hsuan Chang and Jeffrey M. Rosen

16. Adipose tissue-derived stem cells in regenerative medicine and impact on cancer Praveena S. Thiagarajan, Justin D. Lathia, and Ofer Reizes

Section IV. Clinical Applications

17. From Research to the Clinic: Targeting Stem Cell Pathways in Cancer Austin Gurney and Timothy Hoey

18. Targeted Therapies for Glioma Stem Cells Swetha J. Sundar, James Wright, Jason K. Hseih & Andrew E. Sloan

19. Circulating tumor cells, cancer stem cells, and emerging microfluidic detection technologies with clinical applications Molly Kozminsky and Sunitha Nagrath

---