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Biological chemistry has changed since the completion of the human genome project. There is a renewed interest and market for individuals trained in biophysical chemistry and molecular biophysics. The Physical Basis of Biochemistry, Second Edition , emphasizes the interdisciplinary nature of biophysical chemistry by incorporating the quantitative perspective of the physical sciences without sacrificing the complexity and diversity of the biological systems, applies physical and chemical principles to the understanding of the biology of cells and explores the explosive developments in the area of genomics, and in turn, proteomics, bioinformatics, and computational and visualization technologies that have occurred in the past seven years. The book features problem sets and examples, clear illustrations, and extensive appendixes that provide additional information on related topics in mathematics, physics and chemistry.

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PREFACE

PART I: Principles of Biophysical Inquiry
Chapter 1 Introduction: "To the Student"
Chapter 2 Philosophy and Practice of Biophysical Study
Chapter 3 Overview of the Biological System Under Study - Descriptive Models
Chapter 4 Physical Thoughts, Biological Systems - The application of modeling principles to understanding biological systems
Chapter 5 Probability and Statistics
PART II: Foundations
Chapter 6 Physical Principles: Energy - The Prime Observable
Chapter 7 Biophysical Forces in Molecular Systems
Chapter 8 An Introduction to Quantum Mechanics
Chapter 9 Chemical Principles
Chapter 10 Measuring the Energy of a System: Energetics and the First Law of Thermodynamics
Chapter 11 Entropy and the Second Law of Thermodynamics
Chapter 12 Which Way Did That System Go? The Gibbs Free Energy
Chapter 13 The Thermodynamics of Phase Equilibria

PART III: Building a Model of Biomolecular Structure
Chapter 14 Water: A Unique Structure, A Unique Solvent
Chapter 15 Ion-Solvent Interactions
Chapter 16 Ion-Ion Interactions
Chapter 17 Lipids in Aqueous Solution
Chapter 18 Macromolecules in Solution
Chapter 19 Molecular Modeling - Mapping Biochemical State Space
Chapter 20 The Electrified Interphase

PART IV: Function and Action Biological State Space
Chapter 21 Transport and Kinetics: Processes Not at Equilibrium
Chapter 22 Flow in a Chemical Potential Field: Diffusion
Chapter 23 Flow in an Electrical Field: Conduction
Chapter 24 Forces Across Membranes
Chapter 25 Kinetics - Chemical Kinetics
Chapter 26 Bioelectrochemistry - Charge Transfer in Biological Systems

PART V: Methods for the Measuring Structure and Function
Chapter 27 Separation and Characterization of Biomolecules Based on Macroscopic Properties (with Kristin E. Bergethon)
Chapter 28 Determining Structure by molecular interactions with photons: Electronic Spectroscopy (with Kristin Bergethon)
Chapter 29 Determining Structure by molecular interactions with photons: ScatteringPhenomena
Chapter 30 Analysis of Structure - Microscopy
Chapter 31 Epilogue
Chapter 32 Physical Constants

PART VI: APPENDICES
Appendix A Review of Mathematical Methods
Appendix B Quantum Electrodynamics
Appendix C The Pre-Socratic Roots of Modern Science
Appendix D The Poisson Function
Appendix E Assumptions of a Kinetic Theory of Ideal Gas Behavior
Appendix F Determination of a Field from the Potential
Appendix G Geometric Optics
Appendix H The Compton Effect
Appendix I Hamilton´s Principle of Least Action/Fermat´s Principle of Least Time
Appendix J Energy of Interaction between ions
Appendix K Derivation of the Statement, Qrev Qirrev
Appendix L Derivation of the Clausius-Clapeyron Equation
Appendix M Derivation of the van´t Hoff Equation for Osmotic Pressure
Appendix N Pseudoforces
Appendix O Work of charging and discharging a rigid sphere
Appendix P Review of Electrical Circuits
Appendix Q Fermi´s Golden Rule
Appendix R Adiabatic vs non-Adiabatic processes

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