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This second edition provides updated and expanded chapters that critically address the issues or rodent stroke modeling, from choosing the model and outcome measures, designing the experiment, conducting and analyzing it, to reporting it in a scientific publication. Rodent Models of Stroke, Second Edition aims to help its readers understand the limitations and the opportunities of modeling stroke in rodents and enable them to conduct experiments which will not only improve our understanding of the pathophysiology of this devastating disorder but also serve as the basis for developing new highly effective treatments. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.

Authoritative and practical, Rodent Models of Stroke, Second Edition provides authoritative reviews of the most commonly used, well-honed approaches in the field today.

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1. From Bedside to Bench: How Clinical Reality Should Instruct Stroke Modeling

Dirk M. Hermann and Thorsten R. Doeppner

2. How to Avoid Bumping into the Translational Roadblock

Malcolm Macleod and Emily Sena

3. Modeling Focal Cerebral Ischemia in Rodents: Introduction and Overview Vincent Prinz and Matthias Endres

4. Focal Cerebral Ischemia in the Mouse and Rat by Intraluminal Suture

Ludmila Belayev, Matthias Endres, and Vincent Prinz

5. Focal Ischemia Models: Middle Cerebral Artery Occlusion Induced by Electrocoagulation, Occluding devices and Endothelin-1

I Mhairi Macrae

6. Mouse Model of in situ Thromboembolic Stroke and Reperfusion

Orset Cyrille, Le Béhot Audrey, Bonnet Anne-Laure, Maysami Samaneh, and Vivien Denis

7. Photochemical Models of Focal Brain Ischemia

Anja Urbach and Otto W. Witte


8. Housing in an Enriched Environment - A Tool to Study Functional Recovery after Experimental Stroke

Karsten Ruscher and Tadeusz Wieloch

9. Modeling Risk Factors and Confounding Effects in Stroke

Barry McColl, David Howells, Nancy Rothwell, and Adam Denes

10. Effect of Anesthesia in Stroke Models

Richard J. Traystman

11. Non-invasive Brain Imaging in Small Animal Stroke Models: MRI, PET and SPECT

Abraham Martín, Pedro Ramos-Cabrer, and Anna M. Planas

12. Non-invasive Optical Imaging in Rodent Models of Stroke
Markus Vaas and Jan Klohs

13. Behavioral Testing in Rodent Models of Stroke, Part I

René Bernard, Mustafa Balkaya, and André Rex

14. Behavioral Testing in Rodent Models of Stroke -Part II

Gerlinde A.S. Metz

15. Combining Classical Comprehensive With Ethological Based, High Throughput Automated Behavioral Phenotyping for Rodent Models of Stroke

Anne-Christine Plank, Stephan von Hörsten, and Fabio Canneva

16. Histology and Infarct Volume Determination in Rodent Models of Stroke

Clemens Sommer

17. Ethics of Modeling of Cerebral Ischemia in Small Animals

Ute Lindauer

18. Quality Control and Standard Operating Procedures

Ulrich Dirnagl

19. Statistics in Experimental Stroke Research: From Sample Size Calculation to Data Description and Significance Testing

Ulrich Dirnagl

20. Complexities, Confounders, and Challenges in Experimental Stroke Research: A Checklist for Researchers and Reviewers
Ulrich Dirnagl

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