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The first part of this work reports the preparation of some ,beta- unsaturated carbonyl compounds which are useful as starting materials to produce new different types of heterocyclic compounds. In this part of study, we report the relation of 2-acetyl-naphthalene with some aldehydes to give the corresponding ,beta- unsaturated carbonyl compounds (Ia-c). The condensation of these compounds with some carbon and/or nitrogen nucleophiles gave the appropriate pyridine, pyrazole, oxazole derivatives. Biological activity for the synthesized compounds have been studied for anticancer evaluation, and antimicrobial activity.

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Doctor of Organic Chemistry,Faculty of Science and Arts,Aljouf University,Qurayyat, Kingdom of Saudi Arabia.Researcher of Organic Chemistry,Photo Chemistry Division,National Research Center,Dokki, Giza, Egypt.

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