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Covering pertinent basic science and offering today´s most authoritative guidance on clinical management, Fetal Medicine, 3rd Edition , is a must-have resource for obstetricians and other healthcare professionals involved in care of the fetus. An international team of expert contributors delivers the knowledge and background you need to effectively diagnose and treat fetal disorders - everything from prenatal screening and diagnostic tests to common and rare prenatal conditions, early pregnancy loss, ethical issues, and much more.

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Section 1: Early Fetal Development

1 Early Concepts and Terminology, 2

Patricia Collins

2 Cellular Mechanisms and Embryonic Tissues, 6

Patricia Collins

3 Staging Embryos in Development and the

Embryonic Body Plan, 23

Patricia Collins

4 Teratology, 30

Sarah G. Obican and Anthony R. Scialli

5 Early Pregnancy Failure, 38

Davor Jurkovic and Kuhan Rajah

Section 2: The Placenta

6 The Immunology of Implantation, 48

Ashley Moffett, Y.W. Loke and Andrew Sharkey

7 Development of the Placenta and Its

Circulation, 55

Caroline E. Dunk, Berthold Huppertz and John C. Kingdom

8 Placental Function in Maternofetal

Exchange, 69

Colin Sibley and Mark Dilworth

9 Placental Pathology and Implications for Fetal

Medicine, 78

Neil J. Sebire and John C. Kingdom

Section 3: Fetal Physiology and Pathology

10 Development of the Heart and Cardiovascular

System in Relation to Cardiac Abnormalities, 88

Michael Ashworth

11 Lung Growth and Maturation, 103

Richard Harding, Annie R.A. McDougall and Stuart B. Hooper

12 Development of the Kidneys and Urinary Tract in

Relation to Renal Anomalies, 114

Paul J.D. Winyard

13 The Perinatal Postmortem Examination, 121

J. Ciaran Hutchinson, Susan C. Shelmerdine and Neil J. Sebire

Section 4: Epidemiology

14 Epidemiologic and Research Methods in Fetal

Medicine, 132

Cande V. Ananth and Alan T. Tita

Section 5: Ethics

15 Ethical Issues in Maternal-Fetal Medicine, 139

Wybo J. Dondorp and Guido M. de Wert

Section 6: Prenatal Screening and Diagnosis

16 Principles of Screening, 149

Joshua I. Rosenbloom and George A. Macones

17 Conveying Information About Screening and

Diagnosis, 154

Jenny Hewison, Louise D. Bryant and Jane Fisher

18 Ultrasound and Biochemical Screening for Fetal

Aneuploidy, 161

Howard Cuckle and Ran Neiger

19 Ultrasound Screening for Fetal Abnormalities in

the First Trimester, 176

Caterina M. Bilardo and Frederick Ushakov

20 Evidence for Routine Ultrasound Screening for

Fetal

Abnormalities in the Second and Third

Trimesters,

194

Yalda Afshar, Rashmi Rao, Anahit Martirosian and

Lawrence D. Platt

21 Noninvasive Screening for Cytogenetic Disorders

(Fetal Aneuploidy Including Microdeletions), 202

Karen Wou and Ronald J. Wapner

22 Noninvasive Prenatal Diagnosis for Single-Gene

Disorders, 214

Melissa Hill and Lyn S. Chitty

Contents

Contents vii

23 Invasive Diagnostic Procedures, 225

Anthony O. Odibo and Ganesh Acharya

24 Prenatal Diagnosis of Chromosome

Abnormalities, 233

Colleen G. Bilancia, Mythily Ganapathi and Brynn Levy

25 Advances in Molecular Genetics Including Fetal

Sequencing, 247

Magdalena Walkiewicz and Ignatia B. Van den Veyver

26 Expanded Carrier Screening, 254

Liran Hiersch and Yuval Yaron

27 Prenatal Screening for Thalassemias, 263

Kwok Yin Leung, Patrick Au and Mary Tang

Section 7: Diagnosis and Management of

Fetal Malformations

28 Sonography of the Fetal Central Nervous

System, 275

Luc De Catte, Bart De Keersmaecker, Luc Joyeux and

Michael Aertsen

29 The Heart, 305

Christoph Wohlmuth and Helena M. Gardiner

30 Fetal Lung Lesions, 324

James Cook, Angela Yulia, Colin Wallis and Pranav P. Pandya

31 Congenital Diaphragmatic Hernia, 332

Francesca Maria Russo, Liesbeth Lewi, Jute Richter and

Jan Deprest

32 Abdomen, 340

Jon Hyett

33 Kidney and Urinary Tract Disorders, 351

Roland Devlieger and An Hindryckx

34 Diagnosis and Management of Fetal Skeletal

Abnormalities,

373

Lyn S. Chitty, Louise C. Wilson and Frederick Ushakov

35 Diagnosis and Management of Abnormalities of

the Face, 402

Elisabeth de Jong-Pleij and Caterina M. Bilardo

36 Fetal Hydrops, 427

Sylvie Langlois and R. Douglas Wilson

37 Fetal Tumours, 443

Thomas R. Everett, Rosalind Pratt, Colin R. Butler, Richard J.

Hewitt, Paolo De Cop

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