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This open access book was prepared as a Final Publication of the COST Action IC1406 "High-Performance Modelling and Simulation for Big Data Applications (cHiPSet)" project.

Long considered important pillars of the scientific method, Modelling and Simulation have evolved from traditional discrete numerical methods to complex data-intensive continuous analytical optimisations. Resolution, scale, and accuracy have become essential to predict and analyse natural and complex systems in science and engineering. When their level of abstraction raises to have a better discernment of the domain at hand, their representation gets increasingly demanding for computational and data resources.

On the other hand, High Performance Computing typically entails the effective use of parallel and distributed processing units coupled with efficient storage, communication and visualisation systems to underpin complex data-intensive applications in distinct scientific and technical domains.

It is then arguably required to have a seamless interaction of High Performance Computing with Modelling and Simulation in order to store, compute, analyse, and visualise large data sets in science and engineering. Funded by the European Commission, cHiPSet has provided a dynamic trans-European forum for their members and distinguished guests to openly discuss novel perspectives and topics of interests for these two communities.

This cHiPSet compendium presents a set of selected case studies related to healthcare, biological data, computational advertising, multimedia, finance, bioinformatics, and telecommunications.

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Why High-Performance Modelling and Simulation for Big Data Applications Matters.- Parallelization of hierarchical matrix algorithms for electromagnetic scattering problems.- Tail Distribution and Extreme Quantile Estimation using Non-Parametric Approaches.- Towards efficient and scalable data-intensive content delivery: State-of-the-art, issues and challenges.- Big Data in 5G Distributed Applications.- Big Data Processing, Analysis and Applications in Mobile Cellular Networks.- Medical Data Processing and Analysis for Remote Health and Activities Monitoring.- Towards human cell simulation.- Cloud-based High Throughput Virtual Screening in Novel Drug Discovery.- Ultra Wide Band Body Area Networks: Design and integration with Computational Clouds.- Survey on AI-based multimodal methods for emotion detection.- Forecasting Cryptocurrency Value by Sentiment Analysis: An HPC-oriented Survey of the State-of-the-Art in the Cloud Era.

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